Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro

Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro

Flavonoids, present in fruits, vegetables and traditional medicinal plants, show anticancer effects in experimental systems and are reportedly non-toxic. This is a favorable property for long term strategies for the attenuation of lymph node metastasis, which may effectively improve the prognostic s...

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Bibliographic Details
Main Authors: Junli Hong, Adryan Fristiohady, Chi H. Nguyen, Daniela Milovanovic, Nicole Huttary, Sigurd Krieger, Junqiang Hong, Silvana Geleff, Peter Birner, Walter Jäger, Ali Özmen, Liselotte Krenn, Georg Krupitza
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
intravasation
3D model
flavonoids
FAK
MMP1
CYP1A1
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00220/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00220/full

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