Molecular Docking and Dynamics Simulation Studies Predict Munc18b as a Target of Mycolactone: A Plausible Mechanism for Granule Exocytosis Impairment in Buruli Ulcer Pathogenesis

Molecular Docking and Dynamics Simulation Studies Predict Munc18b as a Target of Mycolactone: A Plausible Mechanism for Granule Exocytosis Impairment in Buruli Ulcer Pathogenesis

Ulcers due to infections with <i>Mycobacterium ulcerans</i> are characterized by complete lack of wound healing processes, painless, an underlying bed of host dead cells and undermined edges due to necrosis. Mycolactone, a macrolide produced by the mycobacterium, is believed to be the to...

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Bibliographic Details
Main Authors: Samuel K. Kwofie, Bismark Dankwa, Kweku S. Enninful, Courage Adobor, Emmanuel Broni, Alfred Ntiamoah, Michael D. Wilson
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Toxins
Subjects:
Buruli ulcer
mycolactone
chaperone proteins
SNARE proteins
Munc18b
Sec61
AT2R
WASP
molecular docking
molecular dynamics
Online Access:https://www.mdpi.com/2072-6651/11/3/181

Internet

https://www.mdpi.com/2072-6651/11/3/181

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