Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Summary: Excessive iron accumulation in the heart causes iron overload cardiomyopathy (IOC), which initially presents as diastolic dysfunction and arrhythmia but progresses to systolic dysfunction and end-stage heart failure when left untreated. However, the mechanisms of iron-related cardiac injury...

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Bibliographic Details
Main Authors: June-Wha Rhee, Hyoju Yi, Dilip Thomas, Chi Keung Lam, Nadjet Belbachir, Lei Tian, Xulei Qin, Jessica Malisa, Edward Lau, David T. Paik, Youngkyun Kim, Beatrice SeungHye Choi, Nazish Sayed, Karim Sallam, Ronglih Liao, Joseph C. Wu
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
iPSC
cardiomyocytes
cardiac spheroids
iron overload cardiomyopathy
DMT1
ebselen
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308676

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http://www.sciencedirect.com/science/article/pii/S2211124720308676

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