Suppressor of cytokine signaling-1 mimetic peptides attenuate lymphocyte activation in the MRL/lpr mouse autoimmune model

Suppressor of cytokine signaling-1 mimetic peptides attenuate lymphocyte activation in the MRL/lpr mouse autoimmune model

Abstract Autoimmune diseases are driven largely by a pathogenic cytokine milieu produced by aberrantly activated lymphocytes. Many cytokines, including interferon gamma (IFN-γ), utilize the JAK/STAT pathway for signal propagation. Suppressor of Cytokine Signaling-1 (SOCS1) is an inducible, intracell...

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Bibliographic Details
Main Authors: Jatin Sharma, Teresa D. Collins, Tracoyia Roach, Shiwangi Mishra, Brandon K. Lam, Zaynab Sidi Mohamed, Antia E. Veal, Timothy B. Polk, Amari Jones, Caleb Cornaby, Mohammed I. Haider, Leilani Zeumer-Spataro, Howard M. Johnson, Laurence M. Morel, Joseph Larkin
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86017-4

Internet

https://doi.org/10.1038/s41598-021-86017-4

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