Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

Objective: Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal. Thus, identifying novel molecular target(s) exerting protective effects against these metabolic imbalances is of enormous medical significance. Sirt6 loss- and gain-of-function studies have generated confou...

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Bibliographic Details
Main Authors: Jason G. Anderson, Giorgio Ramadori, Rafael M. Ioris, Mirco Galiè, Eric D. Berglund, Katie C. Coate, Teppei Fujikawa, Stefania Pucciarelli, Benedetta Moreschini, Augusto Amici, Cristina Andreani, Roberto Coppari
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Molecular Metabolism
Subjects:
SIRT6 overexpression
Sirtuin
Insulin sensitivity
Glucose homeostasis
Diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001738

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http://www.sciencedirect.com/science/article/pii/S2212877815001738

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