Advances of Ribonucleotide Reductase Inhibitors on Cancer

Advances of Ribonucleotide Reductase Inhibitors on Cancer

Ribonucleotide reductase (RR) regulates dNTP production, catalyzing the reduction of ribonucleotide into deoxyribonucleotide diphosphate, which is essential in DNA synthesis and cell proliferation. RR overexpression is related with the tumorigenesis and tumor progression. At present, RR inhibitors h...

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Main Authors: WANG An'ge, WU Zhe, WANG Li, QIU Yunqing
Format: Article
Language:zho
Published: Magazine House of Cancer Research on Prevention and Treatment 2019-08-01
Series:Zhongliu Fangzhi Yanjiu
Subjects:
ribonucleotide reductase
enzyme inhibitors
tumor
Online Access:http://html.rhhz.net/ZLFZYJ/html/8578.2019.19.0100.htm
id doaj-3431f595ada94e5cabc611d99cf475b6
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spelling doaj-3431f595ada94e5cabc611d99cf475b62020-11-25T03:05:17ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782019-08-0146874174510.3971/j.issn.1000-8578.2019.19.01008578.2019.19.0100Advances of Ribonucleotide Reductase Inhibitors on CancerWANG An'ge0WU Zhe1WANG Li2QIU Yunqing3State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, ChinaRibonucleotide reductase (RR) regulates dNTP production, catalyzing the reduction of ribonucleotide into deoxyribonucleotide diphosphate, which is essential in DNA synthesis and cell proliferation. RR overexpression is related with the tumorigenesis and tumor progression. At present, RR inhibitors have been used on clinical cancer treatment, and new anticancer drugs have been developed targeting RR and its subunits, which may provide new options for cancer therapy. This review discusses the structure and function of RR, the role of RR on cancer therapy, and future application of RR inhibitors.http://html.rhhz.net/ZLFZYJ/html/8578.2019.19.0100.htmribonucleotide reductaseenzyme inhibitorstumor
collection DOAJ
language zho
format Article
sources DOAJ
author WANG An'ge
WU Zhe
WANG Li
QIU Yunqing
spellingShingle WANG An'ge
WU Zhe
WANG Li
QIU Yunqing
Advances of Ribonucleotide Reductase Inhibitors on Cancer
Zhongliu Fangzhi Yanjiu
ribonucleotide reductase
enzyme inhibitors
tumor
author_facet WANG An'ge
WU Zhe
WANG Li
QIU Yunqing
author_sort WANG An'ge
title Advances of Ribonucleotide Reductase Inhibitors on Cancer
title_short Advances of Ribonucleotide Reductase Inhibitors on Cancer
title_full Advances of Ribonucleotide Reductase Inhibitors on Cancer
title_fullStr Advances of Ribonucleotide Reductase Inhibitors on Cancer
title_full_unstemmed Advances of Ribonucleotide Reductase Inhibitors on Cancer
title_sort advances of ribonucleotide reductase inhibitors on cancer
publisher Magazine House of Cancer Research on Prevention and Treatment
series Zhongliu Fangzhi Yanjiu
issn 1000-8578
1000-8578
publishDate 2019-08-01
description Ribonucleotide reductase (RR) regulates dNTP production, catalyzing the reduction of ribonucleotide into deoxyribonucleotide diphosphate, which is essential in DNA synthesis and cell proliferation. RR overexpression is related with the tumorigenesis and tumor progression. At present, RR inhibitors have been used on clinical cancer treatment, and new anticancer drugs have been developed targeting RR and its subunits, which may provide new options for cancer therapy. This review discusses the structure and function of RR, the role of RR on cancer therapy, and future application of RR inhibitors.
topic ribonucleotide reductase
enzyme inhibitors
tumor
url http://html.rhhz.net/ZLFZYJ/html/8578.2019.19.0100.htm
work_keys_str_mv AT wangange advancesofribonucleotidereductaseinhibitorsoncancer
AT wuzhe advancesofribonucleotidereductaseinhibitorsoncancer
AT wangli advancesofribonucleotidereductaseinhibitorsoncancer
AT qiuyunqing advancesofribonucleotidereductaseinhibitorsoncancer
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