TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes

TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes

The maintenance of B cell homeostasis requires a tight control of B cell generation, survival, activation, and maturation. In lymphocytes upon activation, increased sensitivity to apoptotic signals helps controlling differentiation and proliferation. The death receptor Fas is important in this conte...

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Bibliographic Details
Main Authors: Julian Staniek, Raquel Lorenzetti, Bianca Heller, Iga Janowska, Pascal Schneider, Susanne Unger, Klaus Warnatz, Maximilian Seidl, Nils Venhoff, Jens Thiel, Cristian Roberto Smulski, Marta Rizzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
B lymphocytes
TRAIL-R
apoptosis
human
TRAIL
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00951/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00951/full

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