Deregulated MicroRNA-21 Expression in Monocytes from HIV-Infected Patients Contributes to Elevated IP-10 Secretion in HIV Infection

Deregulated MicroRNA-21 Expression in Monocytes from HIV-Infected Patients Contributes to Elevated IP-10 Secretion in HIV Infection

Persistent activation and inflammation impair immune response and trigger disease progression in HIV infection. Emerging evidence supports the supposition that excessive production of interferon-inducible protein 10 (IP-10), a critical inflammatory cytokine, leads to immune dysfunction and disease p...

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Bibliographic Details
Main Authors: Xian Wu, Le-Le Zhang, Lin-Bo Yin, Ya-Jing Fu, Yong-Jun Jiang, Hai-Bo Ding, Zhen-Xing Chu, Hong Shang, Zi-Ning Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
interferon-inducible protein 10
microRNA-21
IFN-stimulated gene 15
inflammatory response
HIV infection
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01122/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01122/full

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