The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28

The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28

Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the extracellular antigen-targeting CARs and the intracellular signaling modalities of CARs has not been system...

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Bibliographic Details
Main Authors: Yannick D. Muller, Duy P. Nguyen, Leonardo M. R. Ferreira, Patrick Ho, Caroline Raffin, Roxxana Valeria Beltran Valencia, Zion Congrave-Wilson, Theodore L. Roth, Justin Eyquem, Frederic Van Gool, Alexander Marson, Laurent Perez, James A. Wells, Jeffrey A. Bluestone, Qizhi Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor
CAR T cell
CD28
transmembrane domain
hinge domain
heterodimerization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.639818/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.639818/full

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