Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation.

Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation.

The transcriptional response promoted by hypoxia-inducible factors has been associated with metastatic spread of uveal melanoma. We found expression of hypoxia-inducible factor 1α (HIF-1α) protein in well-vascularized tumor regions as well as in four cell lines grown in normoxia, thus this pathway m...

Full description

Bibliographic Details
Main Authors: Laura Asnaghi, Michael H Lin, Kah Suan Lim, Kah Jing Lim, Arushi Tripathy, Murilo Wendeborn, Shannath L Merbs, James T Handa, Akrit Sodhi, Eli E Bar, Charles G Eberhart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4148307?pdf=render

Internet

http://europepmc.org/articles/PMC4148307?pdf=render

Similar Items