p66ShcA functions as a contextual promoter of breast cancer metastasis

p66ShcA functions as a contextual promoter of breast cancer metastasis

Abstract Background The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate from the cytoplasm to the mitochondria where it s...

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Bibliographic Details
Main Authors: Kyle Lewis, Alex Kiepas, Jesse Hudson, Julien Senecal, Jacqueline R. Ha, Elena Voorand, Matthew G. Annis, Valerie Sabourin, Ryuhjin Ahn, Rachel La Selva, Sébastien Tabariès, Brian E. Hsu, Matthew J. Siegel, Matthew Dankner, Eduardo Cepeda Canedo, Mathieu Lajoie, Ian R. Watson, Claire M. Brown, Peter M. Siegel, Josie Ursini-Siegel
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Lung metastasis
p66ShcA
Reactive oxygen species
Online Access:https://doi.org/10.1186/s13058-020-1245-6

Internet

https://doi.org/10.1186/s13058-020-1245-6

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