Proteomic Analysis Reveals a Predominant NFE2L2 (NRF2) Signature in Canonical Pathway and Upstream Regulator Analysis of Leishmania-Infected Macrophages

Proteomic Analysis Reveals a Predominant NFE2L2 (NRF2) Signature in Canonical Pathway and Upstream Regulator Analysis of Leishmania-Infected Macrophages

CBA mice macrophages (MØ) control infection by Leishmania major and are susceptive to Leishmania amazonensis, suggesting that both parasite species induce distinct responses that play important roles in infection outcome. To evaluate the MØ responses to infection arising from these two Leishmania sp...

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Main Authors: Juliana Perrone Bezerra de Menezes, Ricardo Khouri, Camila Victoria Sousa Oliveira, Antonio Luis de Oliveira Almeida Petersen, Tais Fontoura de Almeida, Flávia R. L. Mendes, Amanda do Amor Divino Rebouças, Amanda Lopes Lorentz, Nívea Farias Luz, Jonilson Berlink Lima, Pablo Ivan Pereira Ramos, Rodrigo Pedro Soares, Jeronimo Nunes Rugani, Gregory A. Buck, Marco Aurélio Krieger, Fabrício Klerynton Marchini, Áislan de Carvalho Vivarini, Ulisses Gazos Lopes, Valéria de Matos Borges, Patricia Sampaio Tavares Veras
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
Leishmania
macrophage
NRF2
CBA mice
iron metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01362/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01362/full

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