EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth

EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth

Abstract Background Activated protein C/endothelial protein C receptor (APC/EPCR) axis is physiologically involved in anticoagulant and cytoprotective activities in endothelial cells. Emerging evidence indicates that EPCR also plays a role in breast stemness and human tumorigenesis. Yet, its contrib...

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Bibliographic Details
Main Authors: Naiara Perurena, Carolina Zandueta, Susana Martínez-Canarias, Haritz Moreno, Silvestre Vicent, Ana S. Almeida, Elisabet Guruceaga, Roger R. Gomis, Marta Santisteban, Mikala Egeblad, José Hermida, Fernando Lecanda
Format: Article
Language:English
Published: BMC 2017-01-01
Series:Journal of Hematology & Oncology
Subjects:
Matricellular
Metastasis
Microenvironment
Sphere cultures
Extracellular matrix
Online Access:http://link.springer.com/article/10.1186/s13045-017-0399-x

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http://link.springer.com/article/10.1186/s13045-017-0399-x

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