Studying the Structural Significance of Galectin Design by Playing a Modular Puzzle: Homodimer Generation from Human Tandem-Repeat-Type (Heterodimeric) Galectin-8 by Domain Shuffling

Studying the Structural Significance of Galectin Design by Playing a Modular Puzzle: Homodimer Generation from Human Tandem-Repeat-Type (Heterodimeric) Galectin-8 by Domain Shuffling

Tissue lectins are emerging (patho)physiological effectors with broad significance. The capacity of adhesion/growth-regulatory galectins to form functional complexes with distinct cellular glycoconjugates is based on molecular selection of matching partners. Engineering of variants by changing the t...

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Bibliographic Details
Main Authors: Anna-Kristin Ludwig, Malwina Michalak, Nadya Shilova, Sabine André, Herbert Kaltner, Nicolai V. Bovin, Jürgen Kopitz, Hans-Joachim Gabius
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Molecules
Subjects:
adhesion
glycoprotein
haemagglutination
lectin
sialylation
Online Access:https://www.mdpi.com/1420-3049/22/9/1572

Internet

https://www.mdpi.com/1420-3049/22/9/1572

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