Green Production of Cladribine by Using Immobilized <i>2′</i>-Deoxyribosyltransferase from <i>Lactobacillus delbrueckii</i> Stabilized through a Double Covalent/Entrapment Technology

Green Production of Cladribine by Using Immobilized <i>2′</i>-Deoxyribosyltransferase from <i>Lactobacillus delbrueckii</i> Stabilized through a Double Covalent/Entrapment Technology

Nowadays, enzyme-mediated processes offer an eco-friendly and efficient alternative to the traditional multistep and environmentally harmful chemical processes. Herein we report the enzymatic synthesis of cladribine by a novel 2′-deoxyribosyltransferase (NDT)-based combined biocatalyst. To this end,...

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Bibliographic Details
Main Authors: Cintia Wanda Rivero, Natalia Soledad García, Jesús Fernández-Lucas, Lorena Betancor, Gustavo Pablo Romanelli, Jorge Abel Trelles
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomolecules
Subjects:
biomimetic silica
enzyme immobilization
glutaraldehyde
entrapment
calcium alginate
antineoplastic drug
Online Access:https://www.mdpi.com/2218-273X/11/5/657

Internet

https://www.mdpi.com/2218-273X/11/5/657

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