Telomere alterations in neurofibromatosis type 1-associated solid tumors

Telomere alterations in neurofibromatosis type 1-associated solid tumors

Abstract The presence of Alternative lengthening of telomeres (ALT) and/or ATRX loss, as well as the role of other telomere abnormalities, have not been formally studied across the spectrum of NF1-associated solid tumors. Utilizing a telomere-specific FISH assay, we classified tumors as either ALT-p...

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Bibliographic Details
Main Authors: Fausto J. Rodriguez, Mindy K. Graham, Jacqueline A. Brosnan-Cashman, John R. Barber, Christine Davis, M. Adelita Vizcaino, Doreen N. Palsgrove, Caterina Giannini, Melike Pekmezci, Sonika Dahiya, Murat Gokden, Michael Noë, Laura D. Wood, Christine A. Pratilas, Carol D. Morris, Allan Belzberg, Jaishri Blakeley, Christopher M. Heaphy
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Acta Neuropathologica Communications
Subjects:
NF1
ATRX
Alternative lengthening of telomeres
Glioma
MPNST
Online Access:http://link.springer.com/article/10.1186/s40478-019-0792-5

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http://link.springer.com/article/10.1186/s40478-019-0792-5

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