Simultaneous quantification of palbociclib, ribociclib and letrozole in human plasma by a new LC-MS/MS method for clinical application.

Simultaneous quantification of palbociclib, ribociclib and letrozole in human plasma by a new LC-MS/MS method for clinical application.

A novel LC-MS/MS method was developed for the quantification of the new cyclin dependent kinase inhibitors (CDKIs) palbociclib and ribociclib and the aromatase inhibitor letrozole used in combinatory regimen. The proposed method is appropriate to be applied in clinical practice due to the simple and...

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Bibliographic Details
Main Authors: Bianca Posocco, Mauro Buzzo, Ariana Soledad Poetto, Marco Orleni, Sara Gagno, Martina Zanchetta, Valentina Iacuzzi, Michela Guardascione, Fabio Puglisi, Debora Basile, Giacomo Pelizzari, Elena Marangon, Giuseppe Toffoli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0228822

Internet

https://doi.org/10.1371/journal.pone.0228822

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