Granzyme A Produces Bioactive IL-1β through a Nonapoptotic Inflammasome-Independent Pathway

Granzyme A Produces Bioactive IL-1β through a Nonapoptotic Inflammasome-Independent Pathway

Bacterial components are recognized by the immune system through activation of the inflammasome, eventually causing processing of the proinflammatory cytokine interleukin-1β (IL-1β), a pleiotropic cytokine and one of the most important mediators of inflammation, through the protease caspase-1. Synth...

Full description

Bibliographic Details
Main Authors: Dagmar Hildebrand, Konrad A. Bode, David Rieß, Daniela Cerny, Anna Waldhuber, Franziska Römmler, Julia Strack, Simone Korten, Joachim H.C. Orth, Thomas Miethke, Klaus Heeg, Katharina F. Kubatzky
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714008432

Internet

http://www.sciencedirect.com/science/article/pii/S2211124714008432

Similar Items