MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma

MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma

Abstract Background A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this stud...

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Bibliographic Details
Main Authors: Pierre-Antoine Bissey, Mona Teng, Jacqueline H. Law, Wei Shi, Jeff P. Bruce, Valentin Petit, Sai W. Tsao, Kenneth W. Yip, Fei-Fei Liu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Cancer
Subjects:
miR-34c
SOX4
TGFβ1
EMT
Nasopharyngeal cancer
Cisplatin
Online Access:http://link.springer.com/article/10.1186/s12885-020-07081-z

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http://link.springer.com/article/10.1186/s12885-020-07081-z

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