Computational design of small transcription activating RNAs for versatile and dynamic gene regulation

The structural basis of RNA-based gene control offers the possibility of de novo design. Here the authors present a computational design approach for Small Transcription Activating RNAs a bacterial RNA regulator that allows for versatile and dynamic control of genes, pathways and genetic circuits.

Bibliographic Details
Main Authors: James Chappell, Alexandra Westbrook, Matthew Verosloff, Julius B. Lucks
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01082-6