Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain

Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain

Abstract Background While NF-κB p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB p50 in aging-associated microglial pro-inflammatory priming is poorly understood. Methods Male NF-κB p50+/+ and NF-κB p50−/...

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Bibliographic Details
Main Authors: Thomas Taetzsch, Savannah Benusa, Shannon Levesque, Christen L. Mumaw, Michelle L. Block
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Aging
NF-κB
Priming
Online Access:http://link.springer.com/article/10.1186/s12974-019-1446-z

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http://link.springer.com/article/10.1186/s12974-019-1446-z

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