α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can internalize α-synuclein fibrils that can seed new inclusions from endogenously expressed α-synuclein. The factors contributing to the spread of pathology a...

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Bibliographic Details
Main Authors: Hisham Abdelmotilib, Tyler Maltbie, Vedad Delic, Zhiyong Liu, Xianzhen Hu, Kyle B. Fraser, Mark S. Moehle, Lindsay Stoyka, Nadia Anabtawi, Valentina Krendelchtchikova, Laura A. Volpicelli-Daley, Andrew West
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Neurobiology of Disease
Subjects:
NACP
SNCA
Prion
Aggregation
Parkinson disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301201

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http://www.sciencedirect.com/science/article/pii/S0969996117301201

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