A preliminary randomized double blind placebo-controlled trial of intravenous immunoglobulin for Japanese encephalitis in Nepal.

BACKGROUND:Japanese encephalitis (JE) virus (JEV) is a mosquito-borne flavivirus found across Asia that is closely related to West Nile virus. There is no known antiviral treatment for any flavivirus. Results from in vitro studies and animal models suggest intravenous immunoglobulin (IVIG) containin...

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Main Authors: Ajit Rayamajhi, Sam Nightingale, Nisha Keshary Bhatta, Rupa Singh, Rachel Kneen, Elizabeth Ledger, Krishna Prasad Bista, Penny Lewthwaite, Chandeshwar Mahaseth, Lance Turtle, Jaimie Sue Robinson, Sareen Elizabeth Galbraith, Malgorzata Wnek, Barbara Wilmot Johnson, Brian Faragher, Michael John Griffiths, Tom Solomon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4401695?pdf=render