Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε
Mutations in the human POLE gene are associated with tumours with high mutational loads. Here the authors provide a structural rationale for the mutagenic activity of the cancer-associated DNA polymerase ε P286R variant.
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-01-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-08114-9 |