Development of Pelubiprofen Tromethamine with Improved Gastrointestinal Safety and Absorption

Development of Pelubiprofen Tromethamine with Improved Gastrointestinal Safety and Absorption

Pelubiprofen (PEL), which is a commercialized non-steroidal anti-inflammatory drug (NSAID), is associated with the risk of gastrointestinal (GI) adverse events following long-term exposure and has poor water-soluble properties. Here, a new pelubiprofen tromethamine (PEL-T) with improved solubility,...

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Bibliographic Details
Main Authors: Ji Yeon Park, Dong Ho Oh, Sang-Wook Park, Bo Ram Chae, Chul Woo Kim, Sang Heon Han, Hyeon Jong Shin, Soo Bin Yeom, Da Yeong Lee, Min Kyu Park, Sang-Eun Park, Jun-Bom Park, Kyung-Tae Lee
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
pelubiprofen tromethamine
solubility
permeability
gastrointestinal safety
absorption
Online Access:https://www.mdpi.com/1999-4923/13/5/745

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https://www.mdpi.com/1999-4923/13/5/745

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