Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors

Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors

Recombinant adeno-associated virus (rAAV) vectors have evolved as one of the most promising technologies for gene therapy due to their good safety profile, high transduction efficacy, and long-term gene expression in nondividing cells. rAAV-based gene therapy holds great promise for treating genetic...

Full description

Bibliographic Details
Main Authors: Ruth Rieser, Johanna Koch, Greta Faccioli, Klaus Richter, Tim Menzen, Martin Biel, Gerhard Winter, Stylianos Michalakis
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
adeno-associated virus
rAAV vector
column purification
empty capsids
ion exchange chromatography
affinity chromatography
Online Access:https://www.mdpi.com/1999-4923/13/5/748

Internet

https://www.mdpi.com/1999-4923/13/5/748

Similar Items