Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors

Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors

Recombinant adeno-associated virus (rAAV) vectors have evolved as one of the most promising technologies for gene therapy due to their good safety profile, high transduction efficacy, and long-term gene expression in nondividing cells. rAAV-based gene therapy holds great promise for treating genetic...

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Bibliographic Details
Main Authors:	Ruth Rieser, Johanna Koch, Greta Faccioli, Klaus Richter, Tim Menzen, Martin Biel, Gerhard Winter, Stylianos Michalakis
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Pharmaceutics
Subjects:	adeno-associated virus rAAV vector column purification empty capsids ion exchange chromatography affinity chromatography
Online Access:	https://www.mdpi.com/1999-4923/13/5/748

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