Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient.

Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient.

In mice, the transcription factor, PLZF, controls the development of effector functions in invariant NKT cells and a subset of NKT cell-like, γδ T cells. Here, we show that in human lymphocytes, in addition to invariant NKT cells, PLZF was also expressed in a large percentage of CD8+ and CD4+ T cell...

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Bibliographic Details
Main Authors: Maggie Eidson, Justin Wahlstrom, Aimee M Beaulieu, Bushra Zaidi, Steven E Carsons, Peggy K Crow, Jianda Yuan, Jedd D Wolchok, Bernhard Horsthemke, Dagmar Wieczorek, Derek B Sant'Angelo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3167854?pdf=render

Internet

http://europepmc.org/articles/PMC3167854?pdf=render

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