Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery – potential antimigraine efficacy

Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery – potential antimigraine efficacy

Abstract Background Racemic isometheptene [(RS)-isometheptene] is an antimigraine drug that due to its cardiovascular side-effects was separated into its enantiomers, (R)- and (S)-isometheptene. This study set out to characterize the contribution of each enantiomer to its vasoactive profile. Moreove...

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Bibliographic Details
Main Authors: Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Kristian A. Haanes, René de Vries, Ruben Dammers, A. J. J. C. Bogers, Antoon van den Bogaerdt, Bruce L. Daugherty, Alexander H. J. Danser, Carlos M. Villalón, Antoinette MaassenVanDenBrink
Format: Article
Language:English
Published: BMC 2019-05-01
Series:The Journal of Headache and Pain
Subjects:
CGRP
Isolated vessels
Isometheptene
Migraine
Organ baths
Vasodilation
Online Access:http://link.springer.com/article/10.1186/s10194-019-1003-2

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http://link.springer.com/article/10.1186/s10194-019-1003-2

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