A Pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication

A Pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication

The universal quorum sensing autoinducer, AI-2, is utilized by several bacteria. Analogs of AI-2 have the potential to modulate bacterial behavior. Selectively quenching the communication of a few bacteria, in the presence of several others in an ecosystem, using analogs of AI-2 is non-trivial due t...

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Bibliographic Details
Main Authors: Herman O. Sintim, Shizuka Nakayama, Sonja Gamby, Min Guo, Jacqueline Smith
Format: Article
Language:English
Published: MDPI AG 2012-03-01
Series:Sensors
Subjects:
AI-2
DPD analog
quorum sensing inhibitor
ester pro-drug
lsr expression
autoinducer cell permeation
autoinducer processing
enteric bacteria
Online Access:http://www.mdpi.com/1424-8220/12/3/3762/

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http://www.mdpi.com/1424-8220/12/3/3762/

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