ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease.

ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease.

Accumulating evidence suggests a crucial role for the unfolded protein response (UPR) in Parkinson's disease (PD). In this study, we investigated the relevance of the UPR in a mouse model of chronic MPTP/probenecid (MPTP/P) injection, which causes severe and persistent degeneration of dopaminer...

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Bibliographic Details
Main Authors: Koji Hashida, Yasuko Kitao, Hirofumi Sudo, Yoshitaka Awa, Shinichiro Maeda, Kazutoshi Mori, Ryosuke Takahashi, Munekazu Iinuma, Osamu Hori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3480445?pdf=render

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http://europepmc.org/articles/PMC3480445?pdf=render

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