Different Pharmacokinetics of Tramadol, O-Demethyltramadol and N-Demethyltramadol in Postoperative Surgical Patients From Those Observed in Medical Patients

Different Pharmacokinetics of Tramadol, O-Demethyltramadol and N-Demethyltramadol in Postoperative Surgical Patients From Those Observed in Medical Patients

Background: Most studies examining tramadol metabolism have been carried out in non-surgical patients and with oral tramadol. The aim of this study was 1) to measure concentrations of tramadol, O-demethyltramadol (ODT), and N-demethyltramadol (NDT) in the surgical patients admitted to the intensive...

Full description

Bibliographic Details
Main Authors: Nenad Neskovic, Dario Mandic, Saska Marczi, Sonja Skiljic, Gordana Kristek, Hrvoje Vinkovic, Boris Mraovic, Zeljko Debeljak, Slavica Kvolik
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
postoperative analgesia
postoperative pain
inflammation
cholinesterase
CYP2D6
O-demethyltramadol
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.656748/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.656748/full

Similar Items