A Conserved TCRβ Signature Dominates a Highly Polyclonal T-Cell Expansion During the Acute Phase of a Murine Malaria Infection

A Conserved TCRβ Signature Dominates a Highly Polyclonal T-Cell Expansion During the Acute Phase of a Murine Malaria Infection

CD4+ αβ T-cells are key mediators of the immune response to a first Plasmodium infection, undergoing extensive activation and splenic expansion during the acute phase of an infection. However, the clonality and clonal composition of this expansion has not previously been described. Using a comparati...

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Bibliographic Details
Main Authors: Natasha L. Smith, Wiebke Nahrendorf, Catherine Sutherland, Jason P. Mooney, Joanne Thompson, Philip J. Spence, Graeme J. M. Cowan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
T-cell
TCR
immune-repertoire
single-cell
Plasmodium chabaudi
malaria
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.587756/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.587756/full

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