A Conserved TCRβ Signature Dominates a Highly Polyclonal T-Cell Expansion During the Acute Phase of a Murine Malaria Infection
CD4+ αβ T-cells are key mediators of the immune response to a first Plasmodium infection, undergoing extensive activation and splenic expansion during the acute phase of an infection. However, the clonality and clonal composition of this expansion has not previously been described. Using a comparati...
Main Authors: | Natasha L. Smith, Wiebke Nahrendorf, Catherine Sutherland, Jason P. Mooney, Joanne Thompson, Philip J. Spence, Graeme J. M. Cowan |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-11-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.587756/full |
Similar Items
-
Immunopathologie des infections Plasmodium chabaudi virulantes et non virulantes dans les souris C57BL/6
by: Tshitenge, Tshibuayi Christine
Published: (2012) -
Human γδ TCR Repertoires in Health and Disease
by: Alina Suzann Fichtner, et al.
Published: (2020-03-01) -
Participação do receptor P2X7 no controle das populações de células TFH e B esplênicas e na proteção contra o Plasmodium yoelii 17XNL
by: Cunha, Isabella
Published: (2018) -
CROSS-REACTIVITY OF TCR REPERTOIRE: CURRENT CONCEPTS, CHALLENGES AND IMPLICATION FOR ALLOTRANSPLANTATION
by: Nicolas eDegauque, et al.
Published: (2016-03-01) -
Single T Cell Sequencing Demonstrates the Functional Role of αβ TCR Pairing in Cell Lineage and Antigen Specificity
by: Jason A. Carter, et al.
Published: (2019-07-01)