Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis

It is unclear if multiple sclerosis (MS) genetic susceptibility can be mediated through perturbations of CNS-intrinsic pathways. Authors show that the rs7665090 risk variant is associated with astrocyte responses that enhance lymphocyte recruitment, and with increased lymphocyte infiltration and les...

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Bibliographic Details
Main Authors: Gerald Ponath, Matthew R. Lincoln, Maya Levine-Ritterman, Calvin Park, Somiah Dahlawi, Mayyan Mubarak, Tomokazu Sumida, Laura Airas, Shun Zhang, Cigdem Isitan, Thanh D. Nguyen, Cedric S. Raine, David A. Hafler, David Pitt
Format: Article
Language:English
Published: Nature Publishing Group 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07785-8

Internet

https://doi.org/10.1038/s41467-018-07785-8

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