Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

Abstract Background Repeated failure of drug candidates targeting Alzheimer’s disease (AD) in clinical trials likely stems from a lack of understanding of the molecular mechanisms underlying AD pathogenesis. Recent research has highlighted synergistic interactions between aggregated amyloid-β (Aβ) a...

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Bibliographic Details
Main Authors: Woo Shik Shin, Jing Di, Qin Cao, Binsen Li, Paul M. Seidler, Kevin A. Murray, Gal Bitan, Lin Jiang
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
Amyloid beta
Tau
Biosensor cell
Oligomer
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13195-019-0541-9

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http://link.springer.com/article/10.1186/s13195-019-0541-9

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