Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections.

Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections.

Calprotectin, the most abundant cytoplasmic protein in neutrophils, suppresses the growth of Staphylococcus aureus by sequestering the nutrient metal ions Zn and Mn. Here we show that calprotectin can also enhance the activity of the SaeRS two component system (TCS), a signaling system essential for...

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Bibliographic Details
Main Authors: Hoonsik Cho, Do-Won Jeong, Qian Liu, Won-Sik Yeo, Thomas Vogl, Eric P Skaar, Walter J Chazin, Taeok Bae
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005026

Internet

https://doi.org/10.1371/journal.ppat.1005026

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