Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA<sub>2</sub>-IIA expression in astrocytes and microglia

Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA<sub>2</sub>-IIA expression in astrocytes and microglia

<p>Abstract</p> <p>Background</p> <p>Activation of glial cells, including astrocytes and microglia, has been implicated in the inflammatory responses underlying brain injury and neurodegenerative diseases including Alzheimer's and Parkinson's diseases. Althoug...

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Bibliographic Details
Main Authors: Simonyi Agnes, Hamilton Jennifer L, Han Dongdong, Cui Jiankun, Ajit Deepa, Mohammad Arwa, Zong Yijia, Sheng Wenwen, Sun Albert Y, Gu Zezong, Hong Jau-Shyong, Weisman Gary A, Sun Grace Y
Format: Article
Language:English
Published: BMC 2011-09-01
Series:Journal of Neuroinflammation
Subjects:
BV-2
HAPI
DITNC
primary astrocytes
primary microglial cells
sPLA2-IIA
iNOS
ERK1/2
filopodia
Online Access:http://www.jneuroinflammation.com/content/8/1/121

Internet

http://www.jneuroinflammation.com/content/8/1/121

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