Expression of EMT-Related Genes in Hybrid E/M Colorectal Cancer Cells Determines Fibroblast Activation and Collagen Remodeling

Expression of EMT-Related Genes in Hybrid E/M Colorectal Cancer Cells Determines Fibroblast Activation and Collagen Remodeling

Collagen, the main non-cellular component of the extracellular matrix (ECM), is profoundly reorganized during tumorigenesis and has a strong impact on tumor behavior. The main source of collagen in tumors is cancer-associated fibroblasts. Cancer cells can also participate in the synthesis of ECM; ho...

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Bibliographic Details
Main Authors: Irina Druzhkova, Marina Shirmanova, Nadezhda Ignatova, Varvara Dudenkova, Maria Lukina, Elena Zagaynova, Dina Safina, Sergey Kostrov, Dmitry Didych, Alexey Kuzmich, George Sharonov, Olga Rakitina, Irina Alekseenko, Eugene Sverdlov
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
cancer-associated fibroblasts
colorectal cancer cells
collagen remodeling
fibroblast activation
epithelial/mesenchymal state
Online Access:https://www.mdpi.com/1422-0067/21/21/8119

Internet

https://www.mdpi.com/1422-0067/21/21/8119

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