A Comprehensive Analysis of Genomics and Metagenomics in a Heterozygote Familial Hypercholesterolemia Family

A Comprehensive Analysis of Genomics and Metagenomics in a Heterozygote Familial Hypercholesterolemia Family

Familial hypercholesterolemia (FH) is an inherited rare disease leading to markedly elevated low-density lipoprotein cholesterol (LDL-C) levels and increased risk for cardiovascular event. Gut microbiota has been implicated as a pivotal contributing factor in hyperlipidemia, however, its role in FH...

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Bibliographic Details
Main Authors: Honghong Liu, Ye Jin, Ran Tian, Siqin Feng, Shuyang Zhang, Chenhong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
familial hypercholesterolemia
LDLR gene mutation
whole exome sequencing
gut microbiota
Prevotella dentalis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.605954/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.605954/full

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