Diurnal Rhythms Spatially and Temporally Organize Autophagy

Summary: Circadian rhythms are a hallmark of physiology, but how such daily rhythms organize cellular catabolism is poorly understood. Here, we used proteomics to map daily oscillations in autophagic flux in mouse liver and related these rhythms to proteasome activity. We also explored how systemic...

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Bibliographic Details
Main Authors: Mikhail Ryzhikov, Anna Ehlers, Deborah Steinberg, Wenfang Xie, Eitan Oberlander, Samuel Brown, Petra E. Gilmore, Reid R. Townsend, William S. Lane, Tamas Dolinay, Kiichi Nakahira, Augustine M.K. Choi, Jeffrey A. Haspel
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719301019