Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles

Host kinases facilitate Plasmodium liver stage (LS) infection, but systematic accounting of important players is lacking. Here, the authors use a computational approach and kinase activity profiles to identify host kinase regulators of LS infection and drugs that could eliminate parasite burden.

Bibliographic Details
Main Authors: Nadia Arang, Heather S. Kain, Elizabeth K. Glennon, Thomas Bello, Denali R. Dudgeon, Emily N. F. Walter, Taranjit S. Gujral, Alexis Kaushansky
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01345-2