FoxM1 inhibition ameliorates renal interstitial fibrosis by decreasing extracellular matrix and epithelial–mesenchymal transition

FoxM1 inhibition ameliorates renal interstitial fibrosis by decreasing extracellular matrix and epithelial–mesenchymal transition

FoxM1 is a transcriptional regulator involved in tumor development, pulmonary fibrosis, and cardiac fibrosis. However, its role in renal interstitial fibrosis (RIF) has yet to be elucidated. We established a TGF-β1-stimulated human proximal tubular epithelial cell (HK-2) model in vitro and a unilate...

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Bibliographic Details
Main Authors: Yanhui Wang, Qiaoling Zhou, Rong Tang, Yuyu Huang, Ting He
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Journal of Pharmacological Sciences
Subjects:
FoxM1
Renal interstitial fibrosis
Extracellular matrix
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300517

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http://www.sciencedirect.com/science/article/pii/S1347861320300517

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