Oxidative 3,3,3-trifluoropropylation of arylaldehydes

Oxidative 3,3,3-trifluoropropylation of arylaldehydes

A reaction between (E)-trimethyl(3,3,3-trifluoroprop-1-en-1-yl)silane (1) and arylaldehydes 2 was triggered by fluoride anions to afford aryl 3,3,3-trifluoropropyl ketones 3 in moderate to good yield. A mechanistic study of this reaction indicated that it occurred via an allyl alkoxide (4). A subseq...

Full description

Bibliographic Details
Main Authors: Akari Ikeda, Masaaki Omote, Shiho Nomura, Miyuu Tanaka, Atsushi Tarui, Kazuyuki Sato, Akira Ando
Format: Article
Language:English
Published: Beilstein-Institut 2013-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
cesium fluoride
organo-fluorine
1,3-proton shift
trifluoromethyl
3,3,3-trifluoropropenyl
Online Access:https://doi.org/10.3762/bjoc.9.279

Internet

https://doi.org/10.3762/bjoc.9.279

Similar Items