Cyclosporine A but Not Corticosteroids Support Efficacy of Ex Vivo Expanded, Adoptively Transferred Human Tregs in GvHD

Cyclosporine A but Not Corticosteroids Support Efficacy of Ex Vivo Expanded, Adoptively Transferred Human Tregs in GvHD

Reshaping the immune balance by adoptive transfer of regulatory T-cells (Tregs) has emerged as a promising strategy to combat undesired immune reactions, including in Graft-versus-Host Disease (GvHD), which is the most lethal non-relapse complication of allogeneic hematopoietic stem cell transplanta...

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Bibliographic Details
Main Authors: Sybille Landwehr-Kenzel, Anne Zobel, Isabela Schmitt-Knosalla, Anne Forke, Henrike Hoffmann, Michael Schmueck-Henneresse, Robert Klopfleisch, Hans-Dieter Volk, Petra Reinke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
transplantation
regulatory T-cells
adoptive cell therapy
tolerance
drug interaction
Graft-versus-Host Disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.716629/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.716629/full

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