Indole Derivatives as Cyclooxygenase Inhibitors: Synthesis, Biological Evaluation and Docking Studies

A new series of 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N′-[(E)-(substituted phenyl) methylidene] acetohydrazide derivatives (S1–S18) were synthesized and evaluated for their anti-inflammatory activity, analgesic activity, ulcerogenic activity, lipid peroxidation, ulcer index and cy...

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Bibliographic Details
Main Authors: Mashooq Ahmad Bhat, Mohamed A. Al-Omar, Mohammad Raish, Mushtaq Ahmad Ansari, Hatem A. Abuelizz, Ahmed H. Bakheit, Ahmed M. Naglah
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/23/6/1250