Post-transcriptional Modulation of Sphingosine-1-Phosphate Receptor 1 by miR-19a Affects Cardiovascular Development in Zebrafish

Post-transcriptional Modulation of Sphingosine-1-Phosphate Receptor 1 by miR-19a Affects Cardiovascular Development in Zebrafish

Sphingosine-1-phosphate is a bioactive lipid and a signaling molecule integrated into many physiological systems such as differentiation, proliferation and migration. In mammals S1P acts through binding to a family of five trans-membrane, G-protein coupled receptors (S1PRs) whose complex role has no...

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Bibliographic Details
Main Authors: Elena Guzzolino, Elena Chiavacci, Neha Ahuja, Laura Mariani, Monica Evangelista, Chiara Ippolito, Milena Rizzo, Deborah Garrity, Federico Cremisi, Letizia Pitto
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
sphingosine-1-phosphate receptor 1
microRNA
zebrafish
cardiovascular development
Holt Oram syndrome
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00058/full

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https://www.frontiersin.org/article/10.3389/fcell.2018.00058/full

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