Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia

Dysfunction of GABAergic neurons in the prefrontal cortex has been reported in schizophrenia. Here, the authors use the apomorphine-susceptible rat, which displays some schizophrenia-like behaviors, and show that interneurons in the medial prefrontal cortex are hypomyelinated, which may contribute t...

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Bibliographic Details
Main Authors: Dorien A. Maas, Vivian D. Eijsink, Marcia Spoelder, Josephus A. van Hulten, Peter De Weerd, Judith R. Homberg, Astrid Vallès, Brahim Nait-Oumesmar, Gerard J. M. Martens
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16218-4