Intermittent parathyroid hormone (1–34) supplementation of bone marrow stromal cell cultures may inhibit hypertrophy, but at the expense of chondrogenesis

Intermittent parathyroid hormone (1–34) supplementation of bone marrow stromal cell cultures may inhibit hypertrophy, but at the expense of chondrogenesis

Abstract Background Bone marrow stromal cells (BMSC) have promise in cartilage tissue engineering, but for their potential to be fully realised, the propensity to undergo hypertrophy must be mitigated. The literature contains diverging reports on the effect of parathyroid hormone (PTH) on BMSC diffe...

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Bibliographic Details
Main Authors: Ena Music, Kathryn Futrega, James S. Palmer, Mackenzie Kinney, Bill Lott, Travis J. Klein, Michael R. Doran
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cell
Chondrogenesis
Hypertrophy
Parathyroid hormone
Microwell
Online Access:http://link.springer.com/article/10.1186/s13287-020-01820-6

Internet

http://link.springer.com/article/10.1186/s13287-020-01820-6

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