Tracing of Human Tumor Cell Lineages by Mitochondrial Mutations

BackgroundPrevious studies have shown the value in studying lineage tracing in slices of human tumors. However, a tumor is not a two-dimensional structure and to better understand how a tumor, and its corresponding metastasis grow, a three-dimensional (3-D) view is necessary.ResultsUsing somatic mit...

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Bibliographic Details
Main Authors: Paulo Refinetti, Stephan Morgenthaler, William G. Thilly, Christian Arstad, Per O. Ekstrøm
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.523860/full